PATENTED
Nucleic Acid Techologies

Aegea Biotechnologies, Inc. is an innovation-driven, core technology company. We believe in the power of our science to transform several large markets----life science, diagnostics, genomics, next generation sequencing (NGS), and therapeutics. We are developing a series of reagents, research kits and in-vitro diagnostic (IVD) products for molecular analysis based on novel, patented and proprietary nucleic acid chemistries and methodologies.

 

AEGEA’s patented technologies, including its jointly assigned “Switch-Blocker” technology for highly sensitive rare mutation detection, give AEGEA’s kits the potential to truly disrupt the multi-billion dollar RUO (Research Use Only) and IVD molecular analyses segments.  AEGEA's kits are designed to deliver assay and test results with unprecedented sensitivity and specificity--quickly and using established assay formats, instrumentation and reagents. In addition , AEGEA offers custom solutions, including assay development and adaptation of its technologies for different platforms, to various types of businesses, including pharmaceutical and biotech companies, diagnostics companies, DNA sequencing companies, and others.

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AEGEA has a total of 11 issued US patents related to nucleic acid technologies, plus foreign equivalents. One of AEGEA’s patents for rare mutation detection is already validated and in clinical use in identifying biomarkers in cancer patients. More than 15,000 patient samples have been analyzed with a publicly listed (NASDAQ) company.

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OUR MARKETS

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MOLECULAR DIAGNOSTICS (MDx)

AEGEA's patented "Switch-Blocker" constructions are important products arising from our Selector Technology.  "Switch-Blocker" constructions address the most urgent priorities of the molecular diagnostics market, which heavily relies on nucleic acid-based technologies for sample preparation, nucleic acid target capture, amplification, detection and analysis. The driving factors of the molecular diagnostics market are better, faster, less expensive assays combined with point-of-care, point-of-use, multiplexing, and quantitative applications.

   

By definition, molecular diagnostic assays detect nucleic acid (RNA or DNA) of disease agents in test samples, such as blood, tissue, bodily fluids or swabs. PCR (polymerase-chain-reaction) is used to amplify selected sections of DNA or RNA  for molecular diagnostic assays. PCR methodologies have many applications in the life science research, MDx, Next Generation Sequencing (NGS), and clinical diagnostic markets. The global PCR market is expected to reach $11.5 billion by 2024. AEGEA’s patented next generation nucleic acid technologies have several applications in this large and growing PCR market. AEGEA's patented "Switch-Blocker" constructions can be used to detect rare mutations associated with cancer and other diseases. In combination with Q-PCR, the "Switch-Blocker" technology can be used to detect extremely rare genetic events at a prevalence of less than 0.01%, even in a vast background of complex genomic wild-type/normal DNA. This elevates the molecular diagnostics assays to a new level of sensitivity in a high throughput, relatively inexpensive format that can be used to make better, more informed clinical and patient decisions.

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NEXTGEN SEQUENCING (NGS)

AEGEA’s technical solutions and intellectual property portfolio are also directly applicable to NextGen Sequencing (NGS). Thanks to huge advances in NGS technology and instrumentation, including dramatically increased speed and reduced cost, the application of NGS to MDx is increasingly attractive and anticipated.

 

The NGS market dynamics are driven by ease of use, greater automation, and the ability to use less skilled labor to perform an assay whether automated or manual. These factors are being incorporated into next generation sequencing, particularly in the areas of biomarker discovery, multiplexing and NGS library preparation. AEGEA technologies are being applied in combination with NGS to enable multiplexed MDx assays that provide high sensitivity results across a broad range of medically significant target sequences for a variety of clinical indications.

 

PCR AMPLIFICATION

The real-time PCR market, which includes kits, fluorescent detection methods and instrumentation, is growing rapidly and is an increasingly important segment of the total PCR market. The PCR market includes a combination of instrument, reagents, and software analysis tools.

   

These opportunities provide a unique combinations of technologies that improve both MDx assay capabilities and, at the same time, facilitate improvements to whole transcriptome and whole genome amplification, library construction, and amplification improvements associated with NGS. AEGEA's "Switch-Blocker" technology has already been used to increase the sensitivity of rare mutations associated with cancer by more than 20,000 fold.

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